Nutriovia

“The identification of a change signature as this is important because it can shed light on public health intervention strategies,” said the main author Elizabeth B. Claus, MD, PHD, of the Brigham and Women’s Hospital neurosurgery department, founding member of the general mass health system Brigham. Claus is also making an appointment at the Yale School of Public Health. “Certain professional risks can be avoidable and identifying them could help prevent gliomas.”

Claus and his colleagues compared the genetic samples of 17 firefighters with tumors to 18 people who had never been firefighters. They found mutations linked to a known “mutational signature” – a single scheme of genetic mutations – in many firefighters, especially among those who had spent more years to fight against fires. Among the non-combatants, the highest signal of the signature was seen among people who had perhaps been exposed to Haloalkenes by other professions, such as painting or being a mechanic.

“In this pilot study, we confirm our previous results of an association between exposure to haloalcanes and at the risk of glioma, we hope that to examine it in larger samples which include both firefighters and other people exposed to haloalkans,” said Claus. “Our efforts to do so will continue via the development of our glioma online register, an effort to study the risks and treatments for people with glioma.”

Disclosure: Elizabeth B. Claus reports the advisory fees of Sernier Pharmaceuticals outside the submitted works. Additional disclosure of the author can be found in the newspaper.

“The identification of a change signature as this is important because it can shed light on public health intervention strategies,” said the main author Elizabeth B. Claus, MD, PHD, of the Brigham and Women’s Hospital neurosurgery department, founding member of the general mass health system Brigham. Claus is also making an appointment at the Yale School of Public Health. “Certain professional risks can be avoidable and identifying them could help prevent gliomas.”

Claus and his colleagues compared the genetic samples of 17 firefighters with tumors to 18 people who had never been firefighters. They found mutations linked to a known “mutational signature” – a single scheme of genetic mutations – in many firefighters, especially among those who had spent more years to fight against fires. Among the non-combatants, the highest signal of the signature was seen among people who had perhaps been exposed to Haloalkenes by other professions, such as painting or being a mechanic.

“In this pilot study, we confirm our previous results of an association between exposure to haloalcanes and at the risk of glioma, we hope that to examine it in larger samples which include both firefighters and other people exposed to haloalkans,” said Claus. “Our efforts to do so will continue via the development of our glioma online register, an effort to study the risks and treatments for people with glioma.”

Disclosure: Elizabeth B. Claus reports the advisory fees of Sernier Pharmaceuticals outside the submitted works. Additional disclosure of the author can be found in the newspaper.

“The identification of a change signature as this is important because it can shed light on public health intervention strategies,” said the main author Elizabeth B. Claus, MD, PHD, of the Brigham and Women’s Hospital neurosurgery department, founding member of the general mass health system Brigham. Claus is also making an appointment at the Yale School of Public Health. “Certain professional risks can be avoidable and identifying them could help prevent gliomas.”

Claus and his colleagues compared the genetic samples of 17 firefighters with tumors to 18 people who had never been firefighters. They found mutations linked to a known “mutational signature” – a single scheme of genetic mutations – in many firefighters, especially among those who had spent more years to fight against fires. Among the non-combatants, the highest signal of the signature was seen among people who had perhaps been exposed to Haloalkenes by other professions, such as painting or being a mechanic.

“In this pilot study, we confirm our previous results of an association between exposure to haloalcanes and at the risk of glioma, we hope that to examine it in larger samples which include both firefighters and other people exposed to haloalkans,” said Claus. “Our efforts to do so will continue via the development of our glioma online register, an effort to study the risks and treatments for people with glioma.”

Disclosure: Elizabeth B. Claus reports the advisory fees of Sernier Pharmaceuticals outside the submitted works. Additional disclosure of the author can be found in the newspaper.