Your mind works additional work at night to burn fat and prevent sugar accidents
The brain controls the release of glucose in a wide range of difficult conditions, including fasting and low blood sugar levels.
However, less attention was paid to his role in daily situations.
In a study published in Molecular metabolismMichigan University researchers have shown that a specific group of neurons in the hypothalamus helps the brain to maintain blood glucose levels under routine conditions.
Over the past five decades, the researchers have shown that the nervous system imbalance can lead to fluctuations in blood glucose levels, especially in patients with diabetes.
Some of these neurons are found in the abdominal nucleus in the hypothalamus, which is an area of the brain that controls hunger, fear, regulates temperature and sexual activity.
“Most studies have shown that this area is involved in blood sugar breeding during emergency situations,” said Alison Avenues, PhD, Assistant Professor of Internal Medicine and Casill Diabetes.
“We wanted to understand whether it is also important to control blood sugar during daily activities because when diabetes develops.”
The group focused on vmhCckbr Nerve cells, which contain a protein called Cholecystokinin B.
They used mouse models that have been activated these neurons.
By monitoring the levels of glucose in the blood, the researchers found that VMHCckbr Nerve cells play an important role in maintaining glucose during normal activities, including the first part of the fasting period between the last meal of the day and waking up in the morning.
Affinati said: “In the first four hours after going to bed, these neurons guarantee that you have enough glucose so as not to become a lack of blood sugar overnight.”
To do this, nerve cells go to burn fat through a process called fat decomposition.
“In the first four hours after you go to bed, these neurons guarantee that you have enough glucose so as not to become a lack of blood sugar overnight.”
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Fat is divided into glycerin production, which is used to make sugar.
When the group activated VMHCckbr Nerve cells in mice, animals have increased the levels of glycerin in their bodies.
These results can explain what is happening in patients with diabetes, as they show an increase in fat decomposition during the night.
Researchers believe that in these patients, VMHCckbr Neurons can be overly active, which contributes to high blood sugar.
However, these neurons only control the decomposition of fat, which provokes the possibility that other cells control the levels of glucose through various mechanisms.
Affinati said: “Our studies show that controlling glucose is not a common key as it was previously thought.”
“Various groups of neurons work together, and everything is running in an emergency. However, under routine conditions, it allows accurate changes.”
The team works to understand how all neurons in the ventral nucleus regulate their functions to regulate sugar levels during different circumstances, including fasting, nutrition and stress.
They are also interested in understanding how the brain and nervous system affects together the body’s control over sugar, especially in the liver and pancreas.
The work was carried out by a team of UM researchers at the CASWLL Institute for Diabetes and who focus on nervous control over metabolism – the roles the brain and nervous system plays in controlling metabolism and disease.
Additional Approach: Owaao Susitation, Abdullah Hashem, keyword, Burton Crila, OB Manda Singer, Singer, Jennifer, Jennifer Wloszekk, BBIGIIL J. Jacawy T
Finance/Disclosure: Research support was provided by the Michigan Diabetes Research Center (NIH Grant P30 DK020572), the virtual pattern center for mouse science – the essence of fake tissue (P30 dk089503); Old Warriors Affairs Department (IK2BX005715); Warren Albert Foundation; Endocrine colleagues Foundation; Marilyn E. Vincent and Novo Nordsk. This work has also been partially supported by Nih Grant K08 DK1297226.
(tagstotranslate) liver disease; obesity; Diet and weight loss; Diabetes; Follow a diet and weight control; pressure; Nutrition research; Social Psychology
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