Why does Alzheimer’s disease attack the center of the brain memory first?

With the support of the Alzheimer’s Research Prize Fund in Virginia and Related Disease Research (Ardraf), the FRALIN Institute for Medical Research at the VTC Sharon Swanger and Shannon Farris understands the reason for the weakness of this field in particular.

Swanger studies how the brain cells communicate through clamps in the brain circles that are not corresponding to the disease, while Farris focuses on how different circuits work in the brain memory center at the molecular level. Their intertwined experience made cooperation a natural epidemic.

“We were studying how the circles differ at the molecular level for a period of time,” said Swiger, an assistant professor at the Research Institute. “This new cooperative project combines practical on the clamps and Shannon on the mitochondria in a way that deals with a large gap in the field of Alzheimer’s disease.”

“This type of support at the state level is very important,” Faris said. “It gives researchers in Virginia the opportunity to ask questions that may eventually make a difference to people with Alzheimer’s disease. It is worthwhile to be part of the research that can help people who face this trip.”

One of the main focus in their research is mitochondria – small structures within the brain cells that provide the energy needed for a variety of cellular functions in neurons including interlocking transmission. In Alzheimer’s disease, mitochondria stops working properly in the context of the disease.

Farris and Swanger realize whether the mitochondria is in a circle related to the weak memory may become carcinogenic, which is a major chemical for multiple neurotransmitters. This excessive load can contribute to the early breakdown of memory circuits.

“The relationship between these cells is one of the first to fail in Alzheimer’s disease,” Faris said. ))

To test their hypothesis, researchers will study the brain tissue of healthy mice and mice with certain aspects of Alzheimer’s diseases. By comparing how mitochondria works and how the brain cells communicate through clamps in each group, they hope to find early signs of stress or failure in the exclusive shell circle.

Swanger and Farris are members of the Fralin Biomedical Institute and also the teaching staff in the Department of Biomedical Sciences and Pathology at the Veterinary Medicine College in Virginia.