Why do some people progress faster. And 400 jin behind it

Some people facilitate in the nineties with the mind and body intact, while others fight diabetes, Alzheimer’s or mobility issues decades ago. Some can resist a bad fall or a pepper of influenza easily, while others do not leave the hospital again.

New research led by Colorado Bulder, published this month in the magazine Geneticsand It sheds light on the reason for this.

In information technology, an international team of participating authors determines more than 400 genes linked to accelerated aging across seven different types. The study reveals that different groups of genes lie behind different types of turbulent aging, also known as weakness, from cognitive decline to mobility issues to social isolation.

The results support support for what is known as the “hypothesis of lime science” – the idea that the treatment of multiple chronic diseases that come with aging, we must treat aging itself.

“To be able to determine the treatments to stop or reverse the accelerated biological aging, you need to know what basic biology is,” said Isabelle Foot, the first author of the paper and post -PhD researcher at the CU Institute for Behavioral Genetics. “This is the biggest study so far to use genetics to try to do so.”

Reorting “weakness”

The study revolves around “Prailty”, which is a comprehensive term for “multi -system physiological decline” that often comes with aging.

More than 40 % of adults over 65 years old is weak.

Doctors usually evaluate weakness using a 30 -point index that measures things such as walking speed, fist strength and number of diseases diagnosed and the amount of social activity. Foot said that the problem is that two people can get the same high level of weakness, although one of them is sharp with his awareness, but he cannot walk and the other is in good physical health but has a bad memory.

This lack of discrimination made it difficult for doctors to make recommendations and scientists to determine the reasons behind unhealthy aging.

“Aging is not just one thing. There are many ways to put it.” “So the question becomes: What are the genes concerned?”

To find out, the team conducted a “association at the genome level” that analyzes DNA and health information from hundreds of thousands of participants in the biological bank in the UK and other general data groups to know the genes associated with 30 symptoms of weakness.

They identified 408 gene associated with the rapid aging/weakness, a significant increase in the genes of 37 genes that have been previously identified.

They found that some genes were strongly linked to a sub -species of unhealthy aging, including: “disability”; “Weak perception”; “Metabolic problems”; “Multiple diseases”; “In general, an unhealthy lifestyle,”; And “limited social support”.

For example, the SP1 gene, associated with the function of immunity and Alzheimer’s disease strongly with the broad “weak” sub -type, was associated, while the FTO gene, a known gene, seemed to be obese, abandoned several different categories of unhealthy aging.

“What this paper does not only determine the sub -faces of turbulent aging, but also proves that there is a completely different biology behind it,” said Cu Buller, chief author of the authors, said. “The next concrete step is to know how to deal with this basic biology.”

Anti -aging pills?

In the short term, the authors indicate that the clinical measurements of weakness – which often appear before specific diseases – are expanded to include the six sub -species.

In this way, a person who has been diagnosed can be directed as weakly cognitive towards treatments to prevent dementia, while someone in the metabolic field may take steps to prevent diabetes or heart disease.

Foote imagines a day when people can get a “multi -genetic risk degree” that provides a more detailed vision about the type of unhealthy aging they are exposed to.

But the holy cup, as you say, will be to determine the molecular paths that drive aging and develop treatments to put the brakes.

Are anti -aging pills on the horizon?

Unlikely.

But can one day the birth control pills to treat a group of lifetime issues related to age, and the other to address many cognitive issues?

It is a confusing idea.

“This paper indicates that it is likely that it is not a single magic to treat all diseases that come with aging, but you may not need to be hundreds anymore.”