When death knocks at the door

Some people seem to understand that they were dying a few months before or weeks of death through an intuitive feeling, even without discussing it. This is especially wonderful in patients with severe diseases, such as cancer, or after the main myocardial infarction (MI) or stroke, as well as in older individuals. Hospital studies have shown that more than 80 percent of cancer patients who died were aware of their peripheral condition. This awareness is approximately 50 percent among patients with cardiovascular disease and more than 70 percent among those who suffer from respiratory disease (1). Of course, for a severe patient, the expectation of death is not unusual. However, for individuals without any clear reason, it may arise from a basic material issue.

A few months before death, some elderly or those with serious diseases may face specific signs. However, this time it is not specific and may differ from person to person. They may lose them appetiteEven for food and drinks, once. Weight loss may occur. They constantly feel tired and tend to sleep more because their bodies begin to maintain energy. They often like to be alone and avoid friendly or family gatherings. Surprisingly how quickly their balance is lost. Although it was fixed before, it may suddenly struggle with the stairs with their coordination failure, which greatly raises the risk of falling. They should use cane or pedestrians before it is too late (2). A person who dies suffers from severe and unpredictable feelings, including mood swings. Fearful It may appear as a new anxiety or unusual calm. They are expected sadness For the future they will miss, and they are memory The focus is selectively on long -term meaningful memories instead of modern events. The family becomes aware of these changes, and patients may also realize that something happens (3).

Distinguished withdrawal from life and isolation

Instead of switching to supernatural The reasons for this awareness of imminent death, we must first review the mechanisms in the bonus system in the brain that is born incentivize The will to live.

The bonus system in the brain is similar to an internal coach that encourages us to survive and prosper. It works through a strong chemical called Dopamine. When we do something necessary to survive, such as eating, drinking water, continuing goals for progress, or communicating with others, this system is released. This creates a feeling of pleasure and contentment, and teaches us to repeat those behaviors that are still life. This process is the biological basis for motives, as the expectation of this good feeling leads us to behave. The expectation of this good feeling leads us to advance and act, nourish our goals and curiosity. It is not only about large bonuses. It provides small shrouds of encouragement for daily tasks, which makes the effort feel attention.

Ultimately, this constant constant reinforcement is a strong force behind the will to live. It turns the basic survival into a pursuit of meaningful experiences, drives us to communicate with the world, search for communications, and find the purpose. When this system works well, it helps us to see life as a rewarding thing and deserves to be followed up. The reward system in the brain also plays an important role in the suppression of both brain and body inflammation. The bonuses system in the brain can indicate through Vague And sympathetic Nervous system To suppress the inflammatory response to the body.

Cancer, mi, stroke, and aging are accompanied by a device that also affects brain function, such as dopamine rewards. However, prolonged inflammation in the body due to severe diseases or aging disrupts most of the mental functions, such as the bonus system and the anti -inflammatory system in the brain. The lack of anti -inflammatory functions in the brain enhances physical inflammation, which in turn exacerbates the function of the brain (4,5).

Inflammation and anhedonia

It was also discussed in my previous message, “cancer can force the brain to surrender”, there is evidence that the inflammatory factors associated with cancer can cross the blood barrier in the brain and affect the dopamine bonus system in the brain. This inflammatory state caused by cancer weakens dopamine function, which leads to AnhedoniaLike the apparent pattern of indifference, disappointment, depressionAnd a deep loss of joy (6).

In general, healthy people can otherwise suffer from the mental and physical signs that have been observed in individuals near death, especially after the age of middle age; However, these signs do not usually appear simultaneously. It is often attributed to transient or depression. After about 50 years of age, the joints gradually begin in inflammation. Metable changes occur, and individuals may develop metabolic diseases such as diabetes, cardiovascular syndrome and obesity. Neurological degenerative diseases such as Alzheimer’s and Parkinson’s disease may appear. This shift can be delayed from a normal condition through the use of appropriate drugs, which are balanced AlertOr regular practice. However, one sign is vital: giving up life, or anhedonia. Loss of hope and the desire to live is a decisive factor that affects our ability to survive, fight diseases, and continue personal goals.

Dopamine system, in addition to protecting the body from inflammatory cases, feeds our ability to try joy from SexHobbies, friendships and pursuit of goals, as well as creativity In solving life problems. While Anhedonia may occur at any stage of life, it is often attributed to depression; It may indicate the disorder of hidden infections. Anhedonia can lead to a feeling of surrender to an inevitable fate, which sometimes leads to that Suicide. Ikigai, a Japanese concept, is a reason to continue living. It encourages people to follow a targeted, longer and healthy life. Some scientists believe that Ikegai is the secret of a longer life in Japan.

Although the reward system is not the most vital in the body, its appropriate function may be an important indication of public health. In this regard, the brain reward system can be considered a target medicine In the elderly and patients with severe diseases to improve their treatment. As long as this system works properly, we are ready to fight for our lives.