This simple diet can help protect memory, even with Alzheimer’s genes

A new study led by researchers from General Brigham, Harvard Chan College of Public Health, and the wide institute at the Massachusetts Institute of Technology and Harvard indicates that following a Mediterranean diet may help reduce the risk of dementia. The study, published in Nature MedicineIt was found that people who wear the highest genetic risk of Alzheimer’s disease benefited more than a Mediterranean diet, indicating a greater decrease in the risk of dementia compared to low genetic risks.

“One of the reasons why we want to study the Mediterranean diet is that it is the only diet that was associated with cognitive benefits in a random experience,” said the author of the first study. “We wanted to see whether this benefit may be different in people with varying genetic backgrounds, studying the role of blood receptors, and small molecules that reflect how the body treats food and performs natural functions.”

Over the past few decades, researchers have learned more about the genetic basis and metabolism of Alzheimer’s and relevant dementia. This is among the most common causes of cognitive decline in the elderly. Alzheimer’s disease is known to have a strong genetic component, with an estimated inheritance by up to 80 %.

One gene in particular, Apolipoprotein E (Patriarchal), It has emerged as the most powerful genetic risk factor for intermittent Alzheimer’s disease – the most common type later develops in life and is not directly inherited with a predictable pattern. People with one copy of APOE4 The variable has a risk above 3 to 4 times to develop Alzheimer’s disease. People with two copies of APOE4 Alternative (is called APOE4 Zigut is actor) has a risk above 12 times more of Alzheimer’s disease than those who do not have.

To explore how the Mediterranean diet can reduce the risk of dementia and influence the blood -related blood receptors, the team analyzed data from 4215 women in the health study of the nurses, after the participants from 1989 to 2023 (the average age of 57 in the first place). To verify the authenticity of their findings, the researchers analyzed similar data from 1,490 men in the study of health professionals, followed from 1993 to 2023.

The researchers evaluated long -term dietary patterns using food frequency and examined the participants of the participants of a wide range of molitors. Genetic data has been used to assess the inherited risks for each participant of Alzheimer’s disease. Then the participants continued over time for new cases of dementia. A subset of 1037 women underwent regular phone tests.

They found that people who follow a Mediterranean diet had a lower risk of dementia and showed a slower cognitive decrease. The preventive effect of the diet was stronger in the high -risk group with two copies of APOE4 The genetic alternative, indicating that the diet may help compensate for genetic risks.

“These results indicate that food strategies, specifically the medium diet, can help reduce the risk of cognitive decline and avoid dementia by influencing the large scale in the main metabolism paths,” said Liu. “This recommendation applies widely, but it may be more important to individuals in a higher genetic danger, such as those that carry two copies of APOE4 Genetic alternative. “

The study restrictions were that the regiment consisted of European origin members. More research is needed in a variety of population.

In addition, although the study reveals important connections, genetics and metabolism are not part of most of the clinical risks of Alzheimer’s. Often people do not know Patriarchal Genetics. More work is needed to translate these results into routine medical practice.

“In future research, we hope we will explore whether targeting the specified interlocations through the diet or other interventions can provide a more specialized approach to reducing the risk of dementia,” said Liu said.

Authorship: In addition to Liu, among the authors of General Praijham, Cherraj M. Vias, Cheng Ping, Denio Dong, Johan Lee, UNA A. Zeliznik, Jay E. Kang, Mullen Wang, Frank B. Among the additional authors Xiao Go, Yanbab A, Vengley Wang, Yu Chang, Yin Chang, Walter C Wellet, and Peter Kraft.

Funding: This study was partially funded by the National Institutes of Health (R00DK119412, R01NR019992, R01ag07489, RF1AG083764, U54Ag089325, P30dk046200, UM1CA186107, P01CA087969, R01HL088521, R01hl060712, U01CA167552, R01HL035464).