This shared sugar builds the T -cabinet cells with cancer is stronger

A new discovery is revealed by the scientists of the Van Endel Institute that glucose, which is the primary cell fuel that operates immune cells, also helps in the internal communication of T -cells and enhances the properties of cancer control. Results may help improve the ability of T -cells to fight cancer and other diseases.

A study describing the work published on September 2 in Cell metabolism.

Joseph Longo, Ph.D., the first author of the study and post -PhD, said at the Role Jones Laboratory, PhD, the first author of the study and post -PhD colleague at the Russell Jones Laboratory, PhD, the first author of the study and post -PhD fellow at the Russell Jones Laborat The immune cells are affected by their environment.

The results reveal that the cells are allocated large parts of glucose to build large particles called glycosphosalipidaids (GSSLS). These sugar fat compounds are essential for the growth of T -cells and the manufacture of proteins used by the T cells to combat cancer.

GSLS helps to create fats rich in fats on the surfaces of Telly cells called fatty rolls, which combine cell signals proteins that direct the T -cell to kill cancer cells. Without gsls, these signals are weaker, which makes T -cells less effective in destroying tumors.

Jones said: “Both T cells and cancer cells benefit from the various nutrients to support varying aspects of their function.” “The more we know about these different fuel sources, the more we can support the capabilities of the fungal cancer of T -cells while developing ways to make cancer cells more vulnerable to the immune attack.”

Among the other authors is Lisa M. Decamp, Brandon M. Oswald, PhD, Robert Teis, Alfredo Reyes Olivos, PhD, Michael S. Daabi, PhD, Abeel E. Colt D. Capan, MS, Kelsey S. Williams, Ph.d. Dominic c. Roy, PhD, from the University of Montreal.

Research that was reported in this post has been supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under the award No. R01ai165722 (Jones). The content is only the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.