The “vomiting” cells are lost in the abbreviation of the hidden recovery that can nourish cancer as well

Now, a new mice study led by researchers at the University of Washington University in Saint -Louis and Baylor Medical College of Medicine revealed an unknown cell clearing that may help the affected cells to return to a stem -like condition. The researchers launched this newly discovered response, taking it from the words of the Greek root that means cellular cleansing.

It was published on the Internet in the magazine Cell reports, The study used the mouse model for stomach injury to provide new visions on how to heal cells, or fail to heal, in response to damage, such as infection or inflammatory disease.

The first author, Jeffrey, said. “So, this cellular cleansing is a quick way to get rid of this mechanism so that it can quickly become a small primitive cell capable of spreading and repairing the injury. We have identified this process in the digestive system, but we doubt that it is related to other tissues as well.”

Braun like the process by “vomiting” or giving up waste that adds an abbreviation mainly, which helps to decline the cell and focus on reorganizing healthy tissues faster than it could be able to make a gradual and controlling deterioration.

As with many shortcuts, this one has possible negative aspects: according to the investigators, the fast formula is fast but chaotic, which may help shed light on how the injury responses occur, especially in the position of chronic injury. For example, persistent platelets in response to infection are a sign of chronic inflammation and frequent cell damage that is a cancer -raising land. In fact, the chaos of the festival of extinguished cellular waste that results from all this cruelty that can also be a way to identify or track cancer, according to researchers.

A new cellular process

The researchers identified harsh poisoning within a regenerative task response called Paligenosis, which was first described in 2018 by the current study author, Jason C. Mills, MD, PhD. Now at the Baylor College of Medicine, Mills started this work while he was a faculty member in the Department of Disease Diseases in Washoo Medicine and Brown who was a researcher after his doctorate in his laboratory.

In the Baljinom, the infected cells turn their normal roles and are subject to the process of re -programming into an immature condition, behaving like stem cells that are divided quickly, as happens during development. Originally, the researchers assumed the decline in cellular machines in preparation for this reinterprection that occurs entirely within the cellular cabin called lysozomat, where waste is digested in a slow and right process.

From the start, the researchers noticed the debris outside the cells. They initially rejected this as unimportant, but the more external waste they saw in their early studies, Brown began to doubt that something was deliberately happening. He used a mouse stomach infection model that has sparked ripe cell re -programming to the condition of stem cells simultaneously, which makes it clear that the “vomiting” response – which now occurs in all stomach cells simultaneously – was a feature of the Palcein, not a mistake. In other words, the vomiting process was not just an accidental leak here and there, but rather the newly identified standard cells and which acted in response to the injury.

Although they discovered the purchase qualifiers during the attendance, the researchers said that the cells could use the harsh platelets to give up waste in other more worrying situations, such as giving mature cells the ability to start like cancer cells.

The downside to reduce its size

While the newly discovered plate process may help the infected cells to move forward through visual disease and regeneration of healthy tissues faster, barter comes in the form of additional waste products that can nourish infections, which makes chronic injuries more difficult to solve and associate with increasing the risk of developing cancer.

Mills said: “In these infectious cells, the Balgeen disease – the reflux to the condition of the stem cells for recovery – is a risk fraught, especially after we have determined the reduction of the size of electrode inside it,” Mills said. “These cells in the stomach are long-lived, and aging cells gain mutations. If many of the older mutant cells return to the cases of stem cells in an attempt to repair the infection-the injuries often feed on inflammation, as is the case during infection-there is an increased risk to acquire, democracy and expand harmful mutations that lead to cancer because these stem cells are upset.”

More research is needed, but the authors are suspected that touch can play a role in sustaining infection and infections in Helicobacter Pilory Infections in the intestine. H. Bilore It is a type of bacteria known as stomach injury and damage, causing ulcers and an increased risk of stomach cancer.

Results can also indicate new treatment strategies for stomach cancer and possibly other GI cancer. I developed Koschik K. Das, Broun and Washo Medical Collaboration, PhD in Medicine, Associate Professor of Medicine, an anti -body associated with parts of cellular waste that is removed during the platelets, providing a way to detect when this process may occur, especially in large quantities. In this way, pole dispersal can be used as a sign of previous cases of cancer that can allow early detection and treatment.

Brown said: “If we have a better understanding of this process, we can develop ways to help encourage the response of healing, and perhaps, in the context of chronic injury, the damaged cells that are subject to chronic diameter are prevented from contributing to the formation of cancer,” said Brown.

This work has been supported by the National Health Institutes (NIH), grant numbers K08dk132496, R21Ai156236, P30DK052574, P30DK056338, R01Dk105129, R01CA239645, F31DK136205, K99gm1593593593593593593593593593593593593593593593593595 F31CA236506; Ministry of Defense, grant number w81xwh-20-1-0630; American digestive system, grant numbers AGA2021-5101 and AGA2024-13-01; And the fellowship of Philip, Sima Nidelman in renewal medicine. The content is only the responsibility of the authors and does not necessarily represent the official views of the National Informatics Institutes.