The parasite that extinguishes your body’s pain warning and infiltrating

Secondary disease is a parasitic infection caused by worms, and a type of worm. The infection occurs during the infected water through activities such as swimming, washing clothes and fishing, when the larvae penetrate the skin. Surprisingly, the worm often evades the discovery of the immune system, unlike bacteria or other parasites that usually cause pain, itching or rash.

In this new study, researchers from the College of Medicine in Toulin aim to know the cause of the parasitic worm Veransia Manson It does not cause pain or itching when it penetrates the skin. Their results show this Q. Manson It leads to a decrease in TRPV1+activity, a protein that sends signals that explain the brain as heat, pain or itching. As part of the sensory sensor in sensory neurons, TRPV1+ organizes immune responses in many scenarios such as infection, allergies, cancer, autoimmune, and even hair growth.

The researchers found this Q. Manson The suppression of TRPV1+ suppression of signals is produced from sending them to the brain, and allowing Q. Manson For a largely discovered skin. probably Q. Manson The molecules that prevent TRPV1+ developed to enhance their survival.

“If we specify and isolate the molecules used by the tip worms to prevent TRPV1+, it may provide a new alternative to the current opioid -based treatments to reduce pain, “Dr. Debroski R. said inflammatory cases.”

The study also found that TRPV1+ is necessary to start protecting the host against S. Mansoni. The activation of the TRPV1+ leads to the fast packing of the immune cells, including GD T cells, lonely, and stems, which stimulate inflammation. This inflammation plays an important role in resisting the host to enter the larvae into the skin. These results highlight the importance of neurons that feel pain and itching in successful immune responses

“Determine the molecules in Q. Manson TRPV1 can be learned+ preventive treatments to support schistosomiasis. We imagine a local factor that activates TRPV1+ to prevent infection from polluting water for individuals at risk of obtaining S. Mansoni,Dr. Herbert said.

In this study, mice were injured S. Mansoi And its evaluation of its sensitivity to the pain as well as the role of TRPV1+ in preventing infection. The following researchers are planning to determine the nature of the secreted worms molecules related to the surface responsible for the TRPV1+ prohibition and specific sub -groups of the GD T cells responsible for immune responses. Researchers also seek to increase the understanding of the neurons in which worms have evolved in their suppression.