The hidden group that loses COVID quickly protects

tracking covid 19 vaccine responses.webp

Two health care workers get Covid-19 vaccines on the same day. Both show strong responses to antibodies at first, but after six months, one remains in good health while the other is shrinking in the virus. A new study published in Science medicine It can help explain this difference.

The researchers tracked the levels of antibodies to individuals after vaccinations and identified four distinct styles of immune response after the first supportive vaccination. It is worth noting that the group that started with the highest levels of antibodies but has witnessed a faster decrease earlier. People with low blood levels of IGA antibodies, which protect the nose and throat were also at a higher risk. The results indicate that monitoring how the levels of antibodies change over time can help in identifying individuals exposed to the risk of infection more.

Under the leadership of Nagoya University in Japan, the research team measured the levels of antibodies in 2,526 people over 18 months to see how the vaccine responses between the first vaccination and later enhanced rings changed. They have developed a sporty classification system for Covid-19 vaccine responses using a long-term tracking and an artificial intelligence-based computer analysis, and become the first to systematically determine and describe the “Fast recovery” group.

The researchers found that immune responses decreased in four clear patterns: some people maintained high levels of antibodies over time (the solid respondents), and others began with strong levels but they quickly lost them (the rapid population), as a third group produced some antibodies that also decreased quickly (respondents), and the rest between (medium respondents).

Immunity that reaches an early top and then falls

According to Schengo Iwami, a great author and professor at the Faculty of Science at Nagoya University, the results of the fast fast group were surprising. “Despite the impressive primary response, they soon discovered Covid-19 from other groups, while the solid respondents have maintained protection for longer periods. We cannot see one-time blood tests for IGG antibodies, the type of antibody that we used for classification, cannot detect this risk.

The infection or subsequent infection indicates the infections that occur after vaccination because the virus overcomes the immune protection provided by vaccines. The researchers found that people whose antibodies faster decreased, either because they started low or quickly decreased (weak respondents and fast -ups), were slightly more likely to get an early penetration infection.

After the supporters of the supporter, 29 % of the participants in the permanent respondent category, 28 % of the weak respondents fell, and 19 % were rapid connotations. The remaining participants showed intermediate patterns. The differences in the rates of achievement between the groups were modest -5.2 % for the solid respondents and 6 % for the weak and the fast.

Infections of penetration related to the levels of antibodies IGA (s)

The study also revealed that the participants who have had infections hacked have lower levels of IGA (S) in their blood after several weeks of vaccination. These antibodies protect the nose and the throat and are the first line of defense against respiratory viruses.

More importantly, researchers have found a strong relationship between IGA (S) levels of blood and nasal IGA levels, indicating that blood tests can reliably indicate the power of immune protection in the airways. As a result, measuring IGA (S) levels in the blood after vaccination may help in identifying individuals at risk of release, especially among weak groups.

While these results provide a basis for future research, Professor Iwami emphasized the importance of identifying the basic biological mechanisms responsible for the rapid decrease in antibody levels in order to develop the most effective vaccination strategies. Previous research indicates factors such as age, genetic contrast, vaccine properties, and environmental effects, including sleep habits, stress levels and medications that are taken at the same time.

Professor Iwami pointed out, “This is the first time that we have been able to collect clearly how people respond to Covid-19 vaccines.” “Determining the fast highway style is especially important-it helps to clarify the reason for some people need to be reinforced closer to others. This may contribute to better vaccination strategies, and if the benefits are worthy of current strategies.

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