The "Back" button for six hours: GAI-17 is due to the damage of the stroke and has overcome Alzheimer's disease

Stroke is said to be the second main cause of death all over the world after heart disease. To prevent the death of nerve cells in the brain, a research group led by a professor of Osaka Metropolitan Hidmesu Nakagima from the Faculty of Graduate Studies of Veterinary Sciences has developed a drug that prevents a protein involved in cell death.

Gapdh is associated with a multi-function protein (glycraldaheide-3-Dhyedrogenase phosphate) is associated with many brain and nervous system diseases. The Gai-17 team has developed, GAPDH assembly inhibitor. When this barrier was given to mice modeling with acute strokes, there was a much lower level of brain cell death and paralysis compared to unspecified mice.

GAI-17 also showed any side effects of anxiety, such as harmful effects on the heart or vascular brain. Moreover, experiments that use Gai-17 have shown an improvement in mice even when giving six hours after stroke.

“It is expected that the GAPDH assembly, which we have developed, will be a single drug that can treat many incurable neurological diseases, including Alzheimer’s disease,” said Professor Nakagima. “To move forward, we will verify the effectiveness of this approach in diseases models other than stroke and encourage more practical research towards achieving a healthy and long -term community.”

The results were published in Iscience.

(Tagstotranslate) heart disease; Alzheimer & amp;#039; S; Pharmacy Pharmacy and Conditions; Alzheimer’s & amp;#039; S; Intelligence brain injury; Stroke