Sweet scent molecule stops the treatment of treatment resistant

Searching for the most recent anti -cancer factors that can overcome this resistance to treatment and destroy “rogue” cancer cells. A group of researchers, led by Dr. Hideyuki Saya, Director of the Oncology Center, Fujita Health University, Japan, revealed the mechanism of anti -cancer activity in Benzeldehyde, a boat responsible for almonds, apricots and figs.

Dr. Saya explains, “In the eighties of the last century, the researchers showed that the anti -cancer activity in Benzeldhyheide and its derivatives. The first author of our studies is the daughter of one of the researchers involved in those early studies, and she was the first author of our studies, and she is the daughter of one of the researchers involved in those early studies, and she was peeled by a strong desire to detect the mechanism behind Benjzidi.” This study, published on the Internet in the British Cancer Journal on May 02, 2025, shows the effect of benchdhyde on the main signal reactions within the cancerous cells and the resulting cellular toxicity.

Early studies have mentioned the ability of the Benkradheidheide to prevent the gradual development of mouse embryonic cells, indicating its potential to prevent the proliferation of fast cells. Here, the anti -cancer effects in the Benitradehyde have been studied using the inlaid mouse model to supply the growing pancreatic cancer.

In cell culture studies, benzadhyd prevented the growth of cancerous cells that resist radiotherapy and as well as those who resist treatment with Osimirinib, a factor that prevents turquoine quinase in the signal factor. Benqdaidheide synergy with radiation to eliminate the previous radiation -resistant cancer cells.

The results of the study revealed that the Benzeldhyide has practiced its anti-cancer effects by preventing signaling protein reactions 14-3-3ζ with Ser²⁸-Histon Histon H3 (H3S28PH). This interaction, the key to the survival of cancer cells, was also responsible for resisting treatment and expressing genes related to the national epithelial blog.

Here, benzaldehyde prevented the vocabulary 14-3-3ζ from Serine28 amino 28 from Heston H3. Consequently, the treatment of benzamheide is reduced from expressing genes responsible for resistance to treatment. Treating mice with the Benzenheid derivative derivative prevents the growth of pancreatic tumors and the suppression of the epidemic to epidemic, thus preventing the spread of cancer to remote organs such as the lungs.

By preventing the reaction key to the survival of cancer cells, the benzdheidheide defeats the treatment and prevents a malignant tumor. Dr. Saya concluded the participation of the effects of their findings, “The protein is 14-3-3ζ long ago a target for cancer treatment, but its direct inhibition is not possible because of its important functions in normal cells. Our results indicate that the inhibition of the interaction between 14-3-3ζ and its customer proteins by Benzaldehde has the possibilities of this problem.”

This study showed that the benzhedehyde is effective against cancer cells that have gained radiation resistance and turquoise inhibitors that are commonly used in cancer treatment. In the long run, this study indicates its potential as an anti -consensual cancer factor, as well as targeted molecular treatments.

Dr. John Saito is a researcher at the Laboratory of Dr. Hudhki Saya, Oncology Center, Fujita Health University. She obtained a doctorate from the Faculty of Medicine at Nihun University. Continuing the legacy of one of her parents, who were the pioneer searching for anti -cancer activity in Benzdadehyde in the 1980s, Dr. Saito revealed the mechanism of Benqsadheed anti -cancer. Her experience includes tumors, pathological physiology, immunology, applied physics, and chemistry.

This work was supported by granting for scientific research from the Ministry of Education, Culture, Sports, Science and Technology in Japan (Kakenhi 19k22568).