Scientists starved worms – then discovered the key that controls aging
The researchers caused an aging -like condition in worms by manipulating the TFB copy factor. Under the normal circumstances, worms were subjected to long -term fasting, followed by regeneration of renewal and appearing renewed. However, in the absence of TFB, the stem cells of the worms fail to recover from the fasting period and instead an aging -like state. This condition is characterized by signs such as DNA damage, the expansion of the nucleus, the interactive types of mitochondria (ROS), and the expression of signs of inflammation, which resemble those observed in mammary aging.
“We offer a model for the study of aging at the level of the entire organism. It provides a tool to explore how aging can be operated and overcome,” explains Adam Antibi, head of study and director at the Max Planck Institute for Biology.
The axis of the growth factor tingb
TFB is a copy factor participating in cellular responses for nutrient availability. It plays an important role in responding to fasting by organizing genetic expression. In its absence, worms try to start growth programs without adequate nutrients, which leads to aging.
“Through our new model, we have had genetic screens to determine the mutations that can circumvent aging. We have identified growth factors, including insulin and Beta Beta (TGFBETA), as explained by ANTEBI.
The axis of TFB-TGFBETA signals is also organized during the interruption of cancer, a condition in which cancer cells remain in asleep and not to survive. In the future, researchers want to test whether the worm model can be used to find new treatments targeting aging cells during aging as well as the stillness of cancer.
(Tagstotranslate) Genetics; Steam cells healthy aging diseases and conditions; New types; Biotechnology and Biomatic Engineering; Molecular biology
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