Scientists reveal the molecule of sports exercise hunger

“Exercise regularly is a strong way to lose weight and protect from obesity-related diseases, such as diabetes or heart disease,” said co-author Dr. Yang Ho, Assistant Professor of Pediatrics-Neurology in Baylor and Denkan NRI. “Exercise helps to lose weight by increasing the amount of energy that the body uses; however, it is likely to participate in other mechanisms as well.”

Researchers have previously discovered that Lac -PHE is the most increasing metabolism – the product of body metabolism – in the blood after intense exercise, not only in mice but also in humans and race. The work of the former team showed that giving Lac-PHe to obese mice has reduced the amount of their food and helped them to lose weight without negative side effects. But so far, scientists have not fully understood how Lac-Phe works to suppress appetite.

“Understanding how Lac-Phe works is important to develop it or similar compounds in treatments that may help people lose weight,” he said. “We looked at the brain because it regulates the behavior of appetite and nutrition.”

The researchers studied two types of brain cells in mice. One type was AGRP, which stimulates hunger and is in the nucleus of the curved in the below. The other type was the PVH neurons in the Paravi nucleus in the hypothalamus. These neurons help in suppressing hunger.

AGRP and PVH neurons work together. Usually, AGRP neurons send signals that prevent PVH neurons, making you feel hungry. But when the AGRP neurons are turned off, PVH neurons become more active, which reduces appetite.

Laboratory members and colleagues have discovered that Lac-PHE directly prevents AGRP neurons, which in turn stimulate PVH neurons. This series of events resulted in less mice. Animal behavior has been normal, indicating that Lac-PHE does not cause unpleasant side effects.

In addition, the team has achieved how Lac-Phe prevents AGRP neurons. He said: “We have found that Lac-PHe works on a protein on the AGRP neurons called Katp, which helps to regulate cell activity.” When Lac-PH is activated these channels in AGRP neurons, cells become less active. “This confirmed that the Katp channel is necessary for the effects of LAC-PHE.”

This research helps to explain how the exercise naturally reduces appetite and improve metabolism. “The results also indicate the exciting possibility of targeting this newly discovered mechanism for weight management,” said co -author Dr. Young Show, co -author Dr. Young Show, who was currently at the University of South Florida.

“This conclusion is important because it helps to clarify how the naturally produced molecule can influence the appetite by interacting with a major brain zone that regulates the weight of hunger and the body,” said co -author Dr. Jonathan Long at Stanford University College.

Although this study focused on mice, the results are promising to humans. Future research will explore how Lac-PH is working in various metabolic situations (such as obesity for travelers), how you travel to the brain and whether it can be used safely and effectively as a treatment.

Among the other contributors to this work are Hailan Liu, Veronica L. Li, Qingzhuo Liu, Yao Liu, Cunjin Su, Hueyxian Wong, Na Yin, Hesong Liu, Xing Fang, Kristine M. McDermott, Hueyzhong Wong, MENG Yu and Longlong Tu and Jonathan C. Yuhan Shi, Olivia Z. Ginnard, Yuxue Yang, Junying Han, Megan E. Burt, Sanika V. Jossy, Chunmei Wang, Yongjie Yang, Benjamin R. Arenkiel and Dong Kong. Authors belong to one or more of the following institutions: Baylor College of Medicine, Stanford University Faculty of Medicine, Institute of Neurological Research at Stanford University, Texas University Hospital in Houston, Boston Children’s Hospital and Harvard University in South Florida.

This work was supported by grants from the US Department of Agriculture/CRIS (51,000-064-01S, 3092-51000-062-04 (B) S, American Heart Association (23post1030352), NIH (F32DK134121, R01DK136479, R01DK136526, T32G1313854, T32GM1385413813853, Sigf Alia Studi Fellowship and Child Research Fellowship in Texas.