Scientists reflect the damage of stroke with stem cells

One of every four adults who suffers from a stroke in their lives, leaving about half of them with remaining damage such as paralysis or poor speech because internal bleeding or the lack of oxygen supply does not irreversibly kill brain cells. There are currently no treatments to fix this type of damage. “For this reason, it is necessary to follow new treatment methods to regenerate the potential brain after diseases or accidents,” says Christian Tokinberg, the scientific head of division in the nervous investigation group at the Institute of Abstract Medicine for Renewal Medicine.

Nerve stem cells have the ability to renew brain tissue, such as one team led by Tackeenberg and post -PhD researcher Rebecca Weber, now convincingly in two studies conducted in cooperation with a group headed by Roslan Rost from the University of Southern California. “The results we find shows that neurons not only form new neurons, but also stimulate other renewal processes,” says Tackeenberg.

New neurons from stem cells

Studies used human nerve stem cells, from which different cells of the nervous system can be formed. Stem cells are derived from the next induced stem stem cells, which in turn can be manufactured from natural human physical cells. In order to achieve them, the researchers have caused a permanent stroke in mice, which are closely similar to the manifestation of stroke in humans. The animals were genetically modified so that the human stem cells do not reject.

One week after incitement to stroke, the research team implanted neurons in the affected brain area and observed subsequent developments using a variety of biochemical methods. Tackeenberg says: “We have found that stem cells have survived for a five -week full analysis period and that most of them turned into neurons, which actually contacted the brain cells already.”

The brain renews itself

Researchers also found other signs of renewal: a new formation of blood vessels, relieving inflammatory response processes and improving the integrity of the blood barrier in the brain. “Our analysis exceeds the scope of other studies, which focused on immediate effects immediately after the transplant,” explains Tackeenberg. Fortunately, stem cell transplantation in mice reversed motor weakness caused by stroke. Evidence was partially delivered by the AI’s mouse gait analysis.

Clinical app is close to reality

When he was designing studies, Tackenberg had its attention on human clinical applications. For this reason, for example, stem cells were manufactured without using animal detectives. The Zurich research team has developed a specific protocol for this purpose in cooperation with the IPS (CIRA) research and application center at Kyoto University. This is important for possible therapeutic applications in humans. Another new vision was discovered is that the stem cell transplant operation works better when it is carried out immediately after a stroke but after a week, the second study was verified. In clinical preparation, the time window can greatly facilitate the preparation and implementation of treatment.

Despite encouraging results of studies, Tackeenberg warns that there is still a job to do. “We need to reduce risks and simplify a possible application in humans,” he says. Tackenberg group, in cooperation with RUUSLAN RUST, is currently a type of safety key system that prevents uncontrolled growth of stem cells in the brain. The delivery of stem cells through vascular injection, which will be more practical than the taste of the brain, is also under development. Initial clinical trials using the inductive stem cells to treat Parkinson’s disease in humans are already ongoing in Japan, according to Tackeenberg reports. “The stroke can be one of the following diseases in which the clinical experiment becomes possible.”