Scientists only set how the body rejects pig members – and how to stop it

The results, which were presented today at ESOT Chongress 2025, determined an important step forward in overcoming the greatest challenge in planting wooden devices: rejection by the human immune system.

Using advanced spatial molecular photography, researchers set how human immune cells interact with pigs in the cultivated organs, revealing early signs of rejection and possible intervention strategies. The study, led by Dr. Valentin Gotyodier and an international cooperative research team (the Paris Institute for the Transplant and Renewal of the Nyu Langone), highlights the main molecular mechanisms that can form the future of the carrier.

One of the most striking discoveries was that human immune cells were found in every part of the pig’s kidney filtering system after the transplant. The researchers noticed the early molecular signs of rejection by antibodies as soon as possible 10 and peak on the 33rd day, which enhances the previous results that rejection begins quickly but progresses over time.² By tracking these immune responses for up to 61 days, the team has set a decisive window for the target therapeutic intervention.

“Our study provides the most detailed molecular map so far for how to involve the human immune system with the college of planted pork,” explained by Dr. Gotoudia. “By identifying the behavior of specific immune cells and genetic expressions, we can improve anti -rejection treatments and improve organ transplantation.”

The innovative approach to studying the vital informational pipeline to distinguish human immune cells from the structural cells of the pigs, allowing the microscopic maps of immunological infiltration patterns. It is worth noting that the baccalaureate and the pipeline cells were the most common types of immune cells in all dots, which confirms its role as main mediators in rejecting the taste of Xenograft.

When targeted therapeutic interventions were presented, the signs of immunity were weakened successfully. In conjunction with new spatial visions on how immune cells interact with pork kidney tissue, this represents a major penetration-paving the way for the most accurate anti-rejection strategies. These developments come at a pivotal time as the first clinical -based clinical experiences of kidney transplantation in the live human beneficiaries begin in 2025.

With the transplantation of Xenotransation ready to address the global organ deficiency crisis, these results are close to researchers, one step by genetically modified pigs, a long -term long -term solution. The next stage will focus on improving anti -rejection treatments, improving genetic adjustments in donor pigs, and developing early detection protocols for monitoring and rejection responses.

“Understanding the specific immune reactions at the molecular level allows us to develop targeted interventions that can prevent rejection before their escalation,” explained by Dr. Jotoudia. “This research sets the basis for pork to humans more secure and more effective in the near future.”

With the acceleration of scientific progress, the researchers remain optimistic with caution that the two genetically modified pigs can become a routine transplant option during the next decade. However, organizational approvals will require a fixed and effective offer for the patient’s various groups.

References:

1. V., Williams, C., Morgan, E., and Al. A new 6000-FLX spatial panel application in swine transplantation to the pig. Submitted at ESOT Chongress 2025; 30^Y June 2025; London, UK.
2. Louipy, A., Goutaudier, V., Giarputo, A. Et al. (2023). The immune response after implanting the kidneys from pig to the kidneys: studying the virtual patterns. The Lancet, 402 (10408), 1158-1169. https://doi.org/10.1016/S0140-6736(23)01855-3
3. Montgomery Ra, Six JM, Lonze Be, Tatapudi Vs, Mangiola M, Wu M, Weldon E, Lawson N, Deterville C, Dieter Ra, Sullivan B, Boulton G, Parent B, PIPER G, Sommer P, Cawthon S, Duggan E, Ayares D, Dandro A, Lorber M, Boeke JD, Pass H, Keating B, Griesemer A, Ali NM, Mehta SA, Stewart Za. The results of two cases from the pig to the kidneys xenotransplantation. N Engl J MED. 2022 May 19; 386 (20): 1889-1898. DOI: 10.1056/Nejmoa2120238. Bamid: 35584156.