Scientists have just found the hidden energy source of cancer cells

The results help explain how cancer cells survive the complex mechanical gloves such as crawling through the exact environment of the tumor, or slipping into porous blood vessels or beating the bloodstream. The discovery of the mechanism can lead to new strategies that put cancer cells before spreading.

Researchers at the CRG center in Barcelona discovered a specialized microscope that could pressure live cells on only three microns, about three years of human hair diameter. Note that, within seconds of pressure, mitochondria in Heilla cells is racing to the surface of the nucleus and an additional ATP pump, the molecular energy source of the cells.

“It forces us to rethink the role of mitochondria in the human body. They are not these fixed batteries that operate our cells, but they are similar to the first respondents who can be called in emergency situations when the cells are literally pressed to the maximum.”

Mitochondria formed a narrow aura that the nucleus was afraid inside. This phenomenon was observed in 84 percent of the Haila Cancer cells, compared to almost nothing in the non -compressed floating cells. Researchers refer to the “NAMS” structures, for the mitochondria associated with the nucleus.

To find out what Nams did, the researchers have published a fluorescent sensor that lights when ATP enters the nucleus. The signal increased by about 60 percent in three seconds of the cells that are pressed. “It is a clear sign that the cells adapt to a strain and re -connect the metabolism,” says Dr. Fabio Bazano, the first co -author of the study.

Subsequent experiments revealed the reason for the importance of increasing strength. Mechanical pressure places the DNA under stress, capturing strands and human genome tangle. Cells rely on ATP repair sets to relieve DNA and reach broken sites to repair damage. The compressed cells that received an additional batch of DNA that were repaired in ATP within hours, while those that do not stop dividing properly.

To emphasize the importance of the disease, the researchers also examined breast biopsies of 17 patients. NAM auras appeared in 5.4 percent of the nuclei on the gaseous tumor fronts compared to 1.8 percent in the heart of the thick tumor, a three -fold difference. “Seeing this signature in the patient’s biopsy convinced us of the importance that goes beyond the laboratory seat,” explains Dr. Retoprata (Reto) Gos, the first author of the co -author of the study.

The researchers also enabled the study of cellular engineering that makes the mitochondria rush possible. Actine threads, the same protein cables that allow muscles to bend, are cores, while the endoplasmic retina throws a network -like network. The study showed that the common scaffold, which captures the physical in place, and forms an aura -like structure. When researchers treated the cells with larroncoline A, a drug that disintegrates the Actine, the NAM formation collapsed and the ted is declined.

If the metastatic cells depend on the NAM era, then medications that prevent the scaffold can make the tumors less invasive without mitochondria poisoning widely and sparing healthy tissues. “The mechanical stress responses are an unstable security vulnerability for cancer cells that can open new therapeutic methods,” says Dr. Ferrena Robricht, a joint author of the study.

While the study looked at the cancer cells, the authors of the study confirm that the phenomenon is likely to be a global phenomenon in biology. Immune cells that pressure the lymph nodes, neurons that extend the branches, and fetal cells during formation, all face similar material powers.

“Wherever the cells are under pressure, Dr. Sdelci is likely to protect that these cells are exposed to the cells.” “It is a completely new layer of organization in cell biology, which is a fundamental shift in our understanding of how cells remain intense periods of physical stress.”