Scientists discover the hidden protein that stops hunger

MC4R is important receptors that are activated by the MSH. It plays a major role in the Cooperative Research Center 1423, where it is described structurally and functionally. Mc4R mutations are among the most common genetic causes of severe obesity. “Knowing the 3D structures of active receptors in interacting with bonds and drugs such as setmelanotide, which we were able to decipher in a previous study, enabled us to better understand new job data,” says Dr. Patrick Schirer, the project leader in CRC 1423 and participating in the study, from the Medical and Medical Institute. Setmeanotide, which is an approved drug, stimulates this future and specifically reduces the feelings of hunger. “We are proud that CRC 1423 has now also contributed to understanding the transfer of receptors and their availability,” says Professor Annette Pick Sikinger, a spokesperson for CRC 1423 and co -author of the study. A total of five projects participated in the Cooperative Research Center in this multidisciplinary research.

Using the microscopic examination of modern fluids and monochrome photography, the team showed that MRAP2 protein mainly changes the localization and behavior of the MC4R brain receptors inside the cells. Flu -biological sensors and foci photography showed that MRAP2 is necessary to transport MC4R to the cell surface, as it can transfer deliciously proven signals.

By revealing this new level of organization, the study indicates therapeutic strategies that mimic or modify MRAP2 and bears the ability to combat obesity and relevant metabolism. Professor Heke Biegemann, the project leader in CRC 1423 and co -author of the Study of the Experimental Endocrine Institute for Children in Charité, confirms that this multidisciplinary and international cooperation enables researchers, using various methods and various experimental methods, to detect the new physiological and physiological aspects.

“This work was an exciting opportunity to apply in the application of many microscopic and biological curricula in cells,” says the second author, who is participating in the study, Dr. Paulo Anibal, a lecturer at the College of Physics and Astronomy at St. Andrews University in the United Kingdom.

This research collected experience in the microscope of the fluorescent of living cells, molecular pharmacy and structural biology from institutions in Germany, Canada and the United Kingdom, indicating the power of multidisciplinary science to reveal new principles for regulating receptors.

About CRC 1423

CRC 1423 is a four-year research center funded by the German Research Corporation (DFG), with five participating institutions: Leipzig University, Martin Luther Haley Whiteburg University, Charity-Unitimidine University of Berlin, Heinrich Hin Dusseldorf University, and the main university medical center. Researchers collaborate from these institutions with backgrounds in biochemistry, biotechnology and mathematical sciences on a multidisciplinary basis to gain a comprehensive understanding of how structural dynamics affects the GPCR function. The Cooperative Research Center includes a total of 19 sub -projects.