Scientists discover the effects of viruses in the blood, which may open the long coffeed puzzle

If their study results are confirmed by other research centers, the vital mark may be the first specific and quantitative measuring indicator to confirm the long length. Currently, doctors are given a diagnosis of long Covid based on a set of symptoms that patients develop after SARS-COV-2 infection.

“If the patient reaches the clinic and is constantly linked to the tone of Kovid, after 12 weeks or more after Covid -19 infection, I give them a virtual diagnosis, but I have no blood tests or biological books to confirm this diagnosis,” said William Strenger, MD, who is investigating at the Landy Institute.

The results of the study, mentioned in the magazine infectionIn detail, the detection of SARS-COV-2 protein fragments inside the exterior vesicles (EVS)-a small size package that occurs naturally helps cells sharing proteins, molitors and other substances. The researchers collected and analyzed blood samples from 14 patients over 12 weeks of exercise training (56 samples in all) in a clinical trial led by Strenger in the long length.

Researchers found 65 distinctive SARS-COV-2 protein fragments inside EVS. These fragments come from the PP1ab protein for the virus, which is the symmetrical enzyme of RNA, which is the key to how to copy the virus itself and makes other viral molecules. This protein is uniquely found in SARS-COV-2, not in uninfected human cells, as Asghar Abbasi, PhD, pointed out at the Lundquist Institute and the first author of the study.

Miscellaneous, researchers found that these viral peptides have shown on each subject, but not all blood clouds, in EVS for long Covid patients and they were not discovered in a separate surveillance group of before birth.

These results add increased evidence that SARS-COV-2 may continue in some body tissues after a long period of initial injury. Some groups assume these continuous viral tanks a role in long length. How the virus reaches the tissues without its usual entry points – such as the brain – remains an open question, and it may be associated with EV molecules.

“We thought that perhaps if the virus is going on or moving in the body, we must try to find out if Evs carry these viral fragments,” Abbasi explained.

This idea has become part of a continuous clinical experience led by doctors. Abbasi and Striner, who were already studying EVS to see if it is associated with changes in the immunity function related to exercise and a feeling of distress after excitement, is one of the common symptoms in these patients.

Patrick Beirut, a associate professor in his study, said: “Despite the promising, it has been observed that the molecular signal of viral peptides inside the study samples is hidden and has not been constantly discovered at every time of blood collection,” said Patrick Beirut, a associate professor in his study. “There is still a lot for emptying that we do not know at this stage.”

For example, he added that researchers do not know whether the same exercise pays the expression of viral programs within the cells, then these viral programs lead to proteins that are thrown, or if there is a permanent tank in those cells, which is just a matter of discovery at a certain time point. Although the specified peptides originated from one of the largest proteins in the virus, researchers did not discover other large proteins that indicate the active viral symmetry. It is possible that the peptides in EVS are just the molecular “garbage” residue after the formation of new viral proteins.

“We (our tests) have not been conducted on people who do not suffer from long symptoms who are currently or who have had Covid,” said Stringer. “This raises the question: Does this continue to remove the garbage from the affected cell Covid, or is this really constant repetition somewhere? I think this is the mechanical issue that must be resolved in future studies.”

Peruvian Education and Research Foundation (PERM) and the UCLA DAVID Geffen Medicine (DGSOM)-VINTURA Province (VCCF) funded this research.