Preventing one super protein is the immune system against cancer

A new study may pave the way for a new generation of cancer treatments – by training the body’s immune system to work more intelligent and multiply more strongly. Under the leadership of a doctoral student, Youssef and Professor Michael Berger from the Faculty of Medicine at the University of Hebrew, in cooperation with Professor Majdalina Huber of the University of Philips in Marburg and Professor Eyal Gottlieb of the Texas University Cancer Center, the international team discovered that microscopic immune cells greatly improved their ability to destroy cancer.

At the heart of the research, there is a strong vision: when TT cells – the main immune system players – forced to re -connect how to convert energy, they become significantly more effective in identifying and attacking tumors.

Professor Berger explains: “By disabled Ant2, we have caused a complete shift in how to produce T cells and use energy,” explains Professor Berger. “This re -programming made her much better to identify and kill cancer cells.” In simpler phrases, the prohibition of this protein imposes immune cells on adapting metabolism, and converting them into stronger, faster and more aggressive cancer fighters.

Posted in Nature CommunicationsThe study focuses on the mitochondria – the “white axis” of the cells. By disrupting the course of a specific energy within the T -cells, the team mainly connected the cell engines, creating a state of increased and effective preparation. The changing T cells showed more endurance, faster repetition, and more severe targeting of cancerous threats.

Perhaps most importantly, the researchers have shown that this metabolic weapons process can be operated not only through genetic adjustments but also with medications – opening the door for possible clinical applications.

This discovery is part of an increased movement in immunotherapy for cancer that focuses not only on the immune system directed but to upgrade its inner machines. While more studies and clinical experiments are needed, the effects of this penetration are promising: new treatments that make fun of the body’s private defenses, they were seized on peak performance.

“This work highlights the extent of metabolism and really deep immunity,” says Professor Berger. “By learning how to control the power source of our immune cells, we may be able to open treatments that are more natural and more effective.”