Krisper is discovers the gene that charges vitamin D and stops tumors in their paths

Now, the researchers showed for the first time in The border in the endocrine This is a specific gene, called SDR42E1It is very important to take over vitamin D from the intestine and more metabolism – a discovery with many possible applications in careful medicine, including cancer treatment.

“Here we show this blocking or inhibitory SDR42E1 Dr. George Nimer, Professor and Associate Dean of Research at the University of Health and Life University at Hamad Bin Khalifa University at Hamad Bin Khalifa University in Qatar, and the author opposite the University of Health and Life at Hamad Bin Khalifa University in Qatar, said, “It has stopped selectively from the growth of cancer cells,” said Dr. George Neymer, Professor and Associate Dean for Research at the University of Health and Life University at Hamad Bin Khalifa University at Hamad Bin Khalifa University in Qatar, and the author opposite the University of Health and Life at Hamad Bin Khalifa University in Qatar.

Wrong copy

NEMER and his colleagues were inspired by previous research that found a specific boom in SDR42E1 The gene on the 16 chromosome to be associated with a deficiency of vitamin D. A boom caused protein pieces, making it inactive.

The researchers used the editing of CRISPR/CAS9 to convert the active shape of SDR42E1 In a line of cells from a patient with colon and rectal cancer, it is called HCT116, in its inactive form. In HCT116 cells, the expression of SDR42E1 is usually abundant, indicating that the protein is necessary for its survival.

Once wrong SDR42E1 A copy was offered, the validity of the cancer cells decreased by 53 %. It changed at least 4,663 genes, “the course of the river”, the levels of its expression, which indicates this SDR42E1 It is a decisive molecular key in many interactions needed for cell health. Many of these genes are usually involved in cancer-related cell signals and the absorption of cholesterol-like molecules-in line with the central role of cholesterol. SDR42E1 In the creation of the calcter.

These results indicate that the inhibition of the gene can selectively kill cancer cells, while leaving the neighboring cells not authorized.

Cut two ways

“Our results open possible new ways in accurate oncology, although clinical translation still requires verification of health and long -term development,” said Dr. Nagham Naviz Hindi, a professor at the Middle East University in Amman, Jordan, and the first author of the study.

But the hunger of the selected cells of vitamin D is not the only possible application that immediately grew up to the minds of researchers. The current results indicate this SDR42E1 It cuts two ways: artificial “communication” levels SDR42E1 In local tissues through genetic technology, it may be useful in the same way, as it takes advantage of many known health effects of Calcreiol.

“because SDR42E1 “We can also target it in any of the numerous diseases in which vitamin D plays a regulatory role,” Nimer said.

“For example, nutrition studies indicated that the hormone can reduce the risk of cancer, kidney disease, autoimmune disorders and metabolism.”

“But these broader applications must be made with caution, as the long -term effects SDR42E1 Indian caution: