It can heal the “skin in the syringe” by injection without scars

As long as we have healthy skin, we do not think much. However, if we have great injuries or other injuries, it becomes clear that the skin is to protect the body from the outside world. Thus, helping the body to restore the skin barrier after a dangerous burning can be a matter of life and death.

Large burns are often treated by planting a thin layer of the upper part of the skin, skin. This consists mainly of one cell type. Only transplanting this part of the skin leads to severe scars.

Under the skin, there is a thicker and more advanced layer of skin called the dermis. It has blood vessels, nerves, hair follicles and other structures needed for the function of the skin and elasticity. However, the dermis transplant is rarely an option, as the procedure leaves a large wound like the wound that must be cured.

The trick is the creation of a new skin that does not become a scar tissue but the working dermis.

Johan Johnker, a researcher at the Al -Suwaidi Center, says, “The delegation is so complicated that we cannot grow it in a laboratory,” says Johan Johnker, a Swedish center, says. Advanced healthcare materials.

It is easy to remove the type of most common cell in the dermis, the connective tissue cell or fiber cells, from the body and grow in the laboratory. The connective tissue cell also has the ability to develop into more specialized cells depending on what is required. The researchers behind the study provides a scaffold by the cells grow on small gelatin, a leather collagen -like substance. But the liquid that contains these poured beads on the wound will not remain there.

Researchers solution to the problem is to mix gelatin grains with a gel consisting of another substance for the body, hyaluronic acid. When the beads and gel are mixed, they are connected using what is known as Click Chemistry. The result is a gel that can be called the skin, to some extent, the skin in a syringe.

“The gel has a special feature that means it becomes liquid when exposed to light pressure. You can use a syringe to apply it to the wound, for example, and as soon as it is applied it becomes like the gel again,” says Daniel Eli, Professor of Molecular Physics.

In the current study, three -dimensional researchers printed small balls placed under the skin of mice. The results indicate the capabilities of this technology to use to grow the patient’s cells from the minimum of the skin biopsy, which is printed three -dimensional in the graft and applied to the wound.

“We see that the cells remain and it is clear that they produce different substances required to create new signs. In addition, the blood vessels are formed in the baits, which is important for tissues to survive in the body. We find this substance very promising.”

The blood vessels are a key to a variety of applications for engineering -like materials. Scientists can grow cells in 3D materials that can be used to build organs, i.e. small versions of the organs. But there is the bottle cervix as it relates to these tissue models. They lack blood vessels to transport oxygen and nutrients to cells. This means that there is an end to you that you can get structures before the cells in the middle die from oxygen and nutrient lack.

LIU researchers may be a single step from solving the problem of supply vascular. In another article, it was also published in Advanced healthcare materials, tResearchers describe a method for making threads of materials consisting of 98 percent of water, known as water gels.

“Become hydrogen threads are completely flexible, so we can tie a knot on it. We also explain that they can be formed into small tubes, which can pump fluids or grow blood vessels,” says Daniel Eli.

Miniature tubes, or manageable channels as researchers call them, open new possibilities for developing the blood vessels of EG Organoids.

Participated in the project, Lars Colby, a professor of plastic surgery at the Sahlsrska University Hospital in Gothenburg. The research has received funding from, among other things, Erling-Persson Foundation, European Research Council (ERC), Swedish Research Council, KNUT and Alice Wallenberg.