Hidden bacterial molecules in the brain reveal new sleep secrets

A new research from Washington State University proposes a new model of understanding sleep, which indicates that a substance in the walls of the network -like bacteria, known as the peptideglycan, is naturally present in mice brains and is closely compatible with the sleep cycle.

These results are updating a wider hypothesis that has evolved in WSU for years – as it suggested that sleep arise from communication between body sleep regulation systems and many microbes that live within us.

Erika Enklish, a WSU PhD candidate and the lead author in two scientific papers published recently, WSU doctoral candidate and the main author in two recently published scientific papers, said a doctoral candidate in WSU and a two -year -old leader who was recently published, where the recently published results presented the recently published results.

This sleep view that arises from the “Holobiont” this is an increasing group of evidence that our intestinal microbiomics plays an important role in perception, appetite, sexual engines and other activity-a point of view that turns into traditional models focusing on the brain for sleep.

The recent results related to Petidoglikan, or PG, give weight to this hypothesis and indicate a possible organizational role for bacterial cell wall products in sleep. PG is known to promote sleep when injecting animals, but until recently, the traditional view saw that it had not migrated naturally to the brain.

The English language found that PG, along with the particles of its receptors participating in PG and communication signals, were present in different locations inside the brain, at levels that changed over time of today and sleep deprivation.

The results were reported in July in Boundaries; WSU Sleep researcher and assignment professor James Kruger co -authored the paper. The English language is also a leading author in a modern paper with Krager in the magazine Sleep medicine reviews This suggests the hypothesis of “Holobiont” to sleep.

This paper combines two prevailing views. One assumes that sleep is regulated by the brain and nerve systems. Another focuses on “local sleep”, which frames as a result of the accumulation of sleep -like cases between small cell networks throughout the body. Such cases similar to sleeping between the cells were observed in the laboratory, known as the “Sleeping in the dish” model.

With the accumulation of these smaller pockets of sleep, such as the lights that are released at home, the body is tips of vigilance towards sleep.

The new hypothesis integrates those theories, suggests that sleep results from the interaction between the body and the residing microorganisms-two independent systems that interact and interfere.

“It is not one or another, it’s both. They have to work together,” he said. “Sleep is really practical. This happens in many different speeds of different levels of cellular regulation and tissues and comes due to intense coordination.”

Links between microbium and behavior appear on several fronts, indicating that microorganisms that were formed in the intestine play an important role in basic human perceptions and behaviors. This work raises the traditional view of human neuroscience, which indicates that it is not from top to bottom-that is, the result of decision-making in the brain-but from the bottom to the top-driven by small organisms that formed their animals formed by their hosts and whose needs affect their activities and recognition of their hosts.

“Today,” said Kruger, who was called “a live legend in sleep research” by the Sleep Research Association in 2023. “Today.

The work of the English language expands on the well -known links between bacteria and sleep, including the fact that sleep patterns affect the function of the intestinal microbiome and that bacterial infections cause more people.

The new results begin to go into questions that look forward to the English language to explore more.

She said: “Now that the world has become worth how important microbes are, not only for diseases but also for health, it is very time to start expanding our understanding of how to communicate with our microbes and how our microbes communicate with us.”