Can plastic in your food nourish Azheimer?

After a previous study, it showed how accurate plastic can sneak into all body systems-including the blood barrier in the brain, which protects the brain from small harmful substances such as viruses and bacteria-Professor of URI pharmacy expanded the study to determine the health effects in the brain of plastic toxins. The results of which it find indicate that the accumulation of fine plastic and nanoparticles in the brain can lead to a decrease in cognitive and even Alzheimer’s disease, especially in those who carry genetic risk factors.

The last Russian study, recently published in the magazine Environmental research communicationsThe genetically modified mice to include the natural genes that occur APOE4, which is a strong indicator of Alzheimer’s risk, which makes people more vulnerable 3.5 times more than those who carry the APOE3 alternative to the gene that is transmitted from parents to the offspring.

Ross said: “In these mice, as in people, it is not a guarantee that you will see any changes in perception. You can have identical twins carrying APOE4, one is completely healthy, and the other can have Alzheimer’s disease.” “So he tells us that there is something about lifestyle, something around the environment.

To find out, Ross and her team revealed two groups of mice- one with the APOE4 variable and one with APOE3- to flour plastic and nano in drinking water for three weeks. Small molecules of polystyrene-among the most plastic materials in the world, located in the sterovom containers, plastic cups and more-they sneaked into mice organs, including the brain, as expected. The search included a control set of all APOE assignment that has not received extensive plastic.

The Ross team then operated the mice through a series of tests to examine their cognitive ability, starting with the open field test, as the researchers put the mouse in a room and allowed them to explore at the will for 90 minutes. Usually, the mouse will embrace the walls, and of course try to hide from potential predators. However, after exposure to accurate plastic, the APOE4 mice – especially male mice – tend to wander more in the middle of the room and spend time in open space, leaving themselves vulnerable to predators.

To test its ability to identify new objects, put the rosan of mice in an open room with two distinguished beings. After time to explore the objects, the mice were removed and returned at a later time, this time with a different replacement of an object. Female mice with APOE4 and exposure to accurate plastic were slow to identify new organisms, if they do so at all, a sign of the cognitive decrease that affects memory.

Ross said: “In the first test, you can see males spend more time and rest more in the middle of the square. In females, we saw changes in identifying new organisms,” Ross said. “In human Alzheimer’s patients, men tend to try more changes in indifference; they care less. Women are testing more memory changes. So memory and indifference connection are completely clear: when animals that carry risk factors in humans are exposed to the development of Alzheimer’s disease, we see that there is a change in the field of sexes. Patients.”

The results are related to enough to ensure more study in the cognitive decrease caused by exposure to micro -materials and nanoparticles, which are among the most prominent environmental toxins that people are routinely exposed to. (A separate study of URI in 2023 revealed the extent of accurate plastic accumulation in the environment, and it finds shockingly that the highest incense of the NarraganSett Bay floor contains more than 1,000 tons of flour plastic.)

Ross continues to expand its research on the subject and encourage others to do so, in the hope that it will lead to a better organization of toxins. The Lower Plastic Safety Law, which was introduced in the US House of Representatives in July, would direct the American Food and Drug Administration to study the human health effects of delicate plastic in food and water, and focuses especially on children’s weaknesses, endocrine and reproductive systems, and association with cancer and chronic diseases.

Ross said: “There was not much money spent on the effects of human health of accurate plastic,” noting that it is in a regular discussion with the Congress delegation in Rod Island about the need for organization. “It is interesting that what we see in mice is similar to what we see in the real world. We want to encourage more research on the flour and nano scourge.”