A common supplement can reflect the hidden damage of the almond sugar

Recent publication in Cancer detectionA publication of the American Society for Cancer Research, the study found that patients with melanoma and lung cancer in the non -small cells who consumed high levels of sugar had a worse response to immunotherapy and survival survival than those who had low meals in artificial desalination.

Fightly, the nutritional supplements that have strengthened the levels of the amino acid arginine reduce the negative effects of almond sugar on immunotherapy in mice, a approach that can now be tested in clinical trials.

“We need to meet the patients where they are,” said the lead author Abe OPMC. For this reason, it is so exciting that Arginine supplements can be a simple way to counter the negative effects of almonds on immunotherapy. “

Senior authors Diwakar Davar, Assistant Professor of Medicine in Beit, UPMC Hillman, who collaborated with Overracre and their team, used mouse models to show that the negative effects of almond sugar are driven by disruption on the intestine bacteria.

SUCRALOSE transformed the composition of microbium mouse, which increased bacterial species that analyze argan, which reduced the levels of this amino acid in the blood.

Immune checkpoint inhibitors, such as immunotherapy, such as anti -PD1 action by intensifying T -cell activity so that they can kill cancer cells more effectively. Arginine is necessary for the function of T -cells, especially in cancer.

“When arginine levels were exhausted due to the transformations driven by sugar in the microbium, the cells cannot work properly,” said Overracre. “As a result, immunotherapy was not effective in mice feeding sugar.”

In mouse models of glandular cancer and skin cancer, adding sugar to the diet prevents anti -PD1 treatment, which leads to larger tumors and weak survival. But when researchers gave mice fed by mice or sterolin, which are met to arginine in the body, the effectiveness of immunotherapy has been restored.

To assess the importance of these results for humans, researchers in 132 patients with advanced skin cancer or uneven lung cancer who have received anti -PD1 treatment on its own or in combination with chemotherapy. Patients filled the questionnaires of the history of the detailed diet, which included questions about the number of times they consumed artificial sweeteners in coffee, tea and diet soda.

Davar said: “We have found that sugar has hindered the effectiveness of immune treatments through a group of types of cancer, stages and treatment methods.” “These observations increase the possibility of designing the bibliotic, such as targeted nutrient supplements for patients who consume high levels of sugar.”

The researchers hope to launch a clinical trial that realizes whether the srulin supplements-which enhance the levels of Arginine more than arginine itself-affect the microbiomeum of the intestine and the anti-tumor immune response in patients.

They are also interested in looking at how other sugar alternatives, such as two aspirin, sugar, Xylitol and Stevia, affect the immune system and respond to immunotherapy.

Other authors in the study are Christine Morefar, Mrs. Madison Naguin, Drew Wilvhart, PhD, Zakaria Dahani, Asen Bohr, PhD in Medicine, PhD, Bingian Shi, PhD, PhD, Michael Morikon, PhD, Hunt Niktor Nevis, MD, Dr. Doctorate, Stephen Mallte, Kaitlin Busong, Stacy Gilhaus, PhD, Devia Rajasongram, PhD, Lawrence Kane, PhD, Greg Delgov, PhD, and Jeishno Das, PhD, all in Pitt or UPMC.

This research was supported by the National Institutes of Health (DP2AI177967, S10D023402, S10D032141, R01CA206517, R01Ai138504, T32GM008208, U01 Ca271407, R01 Ca25777265, U01 Ca26806, P506 and P506 and P501 Ca254865), Damon Runyon Cancer Research Poundation and Gateway for Cancer Research (G-22-800).